The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration
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- 作者：Yuanhu Xuana ; 1 ; Lisha Chia ; 1 ; Haishan Tiana ; 1 ; Wanhui Caia ; Congcong Suna ; Tao Wanga ; Xuan Zhoub ; Minglong Shaoa ; Yuting Zhua ; Chao Niua ; Yusheng Sunc ; Weitao Conga ; Zhongxin Zhua ; Zhaoyu Lia ; Yang Wangd ; wy2010@wzmc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Litai Jina ; jin_litai@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：bFGF ; basic Fibroblast Growth Factor ; NF-κB ; nuclear factor kappa B ; c-JNK ; Jun N-terminal kinase ; PI3 K ; phosphatidylinositol 3-kinase ; FGFR ; fibroblast growth factor receptor ; RNA-Seq ; RNA-Sequencing ; IκB-α ; inhibitor of nuclear factor kappa B-alpha ; ECM ; extracellular matrix ; PKC ; protein kinase C ; ERK ; extracellular regulated protein kinases ; MAPK ; mitogen-activated protein kinase ; PAI-1 ; plasminogen activator inhibitor-1 ; TNF-α ; tumor necrosis factor ; GAPDH ; glyceraldehyde-3-phosphate dehyd
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：82
- 期：1
- 页码：28-37
- 全文大小：3460 K
文摘
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RNA-Seq based transcriptome analysis was introduced to isolate bFGF-regulating signal pathways that regulate cell migration.
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Many pathways including Wnt, Hippo, ECM, Hedgehog, and NF-κB signaling pathways are regulated by bFGF signaling.
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We identified bFGF-NF-κB-JNK pathway by which fibroblast cell migration is regulated.
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NF-κB pathway regulates JNK activity is independent of the PI3K-Rac1 signaling pathway.