T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease

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• 作者：Tarja Lö ; nnfors-Weitzel ; MD^a ; ^{Tarja.Loennfors@insel.ch} ; Thilo Weitzel ; PhD^d ; Johannes Slotboom ; PhD^a ; Claus Kiefer ; PhD^a ; Claudio Pollo ; MD^c ; Michael Schü ; pbach ; MD^b ; Markus Oertel ; MD^c ; Alain Kaelin ; MD ; PhD^b ; Roland Wiest ; MD^a
• 关键词：Parkinson's disease ; Deep brain stimulation ; Subthalamic nucleus ; Basal ganglia ; T2 relaxometry
• 刊名：NeuroImage: Clinical
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：832-837
• 全文大小：629 K
• 卷排序：12

文摘

Parkinson's disease features are reflected in spatially resolved measurement of MR T2-relaxation times. Deep brain stimulation therapy target identification can be assisted by measurement of MR T2-relaxation times. T2r asymmetry in the subthalamic nucleus is not associated with increased clinical symptoms, but with response to therapy. Lower boundaries of T2r in the STN predict motor outcome in Deep brain stimulation therapy Patient selection criteria may be improved by including parameters based on MR relaxometry.