Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
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- 作者：Xin Gong1 ; 2 ; 3 ; 7 ; Hongwu Qian1 ; 2 ; 3 ; 7 ; Xinhui Zhou1 ; 2 ; 3 ; 7 ; Jianping Wu1 ; 2 ; 3 ; 7 ; Tao Wan4 ; 7 ; Pingping Cao1 ; 2 ; 3 ; Weiyun Huang1 ; 2 ; 3 ; Xin Zhao1 ; 2 ; 3 ; Xudong Wang4 ; Peiyi Wang5 ; Yi Shi4 ; 6 ; George F. Gao4 ; 6 ; Qiang Zhou1 ; 2 ; 3 ; zhouqiang00@tsinghua.org.cn" class="auth_mail" title="E-mail the corresponding author ; Nieng Yan1 ; 2 ; 3 ; nyan@tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：165
- 期：6
- 页码：1467-1478
- 全文大小：5373 K
文摘
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The cryo-EM structure of full-length human NPC1 was determined at 4.4 Å resolution
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Structure-guided biochemical analysis of cholesterol transfer from NPC2 to NPC1
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Low-resolution cryo-EM structure of NPC1 bound to GPcl of Ebola virus was obtained
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A trimeric GPcl binds to one NPC1 through the crystal structure-revealed interface