Real-time monitoring of blood carbon dioxide tension by fluorosensor

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• 作者：Weizhong  ; Jin ;   ; ^{wzkingfdu@gmail.com} ; Jinjun  ; Jiang ;   ; ^{jinjundoc@163.com} ; Yuanlin  ; Song  ; ;   ; ^{ylsong70@gmail.com} ; Chunxue  ; Bai  ; ;   ; ^{bai.chunxue@zs-hospital.sh.cn}
• 关键词：Blood gas analysis ; Fluorescence ; Sensor
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2012
• 出版时间：15 January 2012
• 年：2012
• 卷：180
• 期：1
• 页码：141-146
• 全文大小：519 K

文摘

A new intravascular fluorosensor was developed and validated for inline monitoring. The sensor was based on the fluorescent indicator 1-hydroxypyrene-3,6,8-trisulfonate. The sensor was then immersed in various solutions in vitro and carotid artery bypass of rabbits in vivo for testing. Changes of in solutions and blood were created by bubbling CO₂/N₂ and hyperventilation/hypoventilation, respectively. The changes of fluorescent intensity over range of 14?50 mmHg was linear. The resolution of the whole sensor system was 1 mmHg, with a bias ¡À SD of ?.1 ¡À 2.9 mmHg and precision ¡À SD of 2.1 ¡À 1.9 mmHg. The sensor signal has been stable during measurement for at least 25 h and was insensitive to fluctuations of ions concentration and osmosis at pathophysiological limits. The performance of the sensor is in agreement with blood gas analyzer in a wide range of and it is qualified for continuous intravascular measurement of blood at various conditions.