Th2/Treg imbalance is disrupted in OVA-induced allergic asthma Site-specific delivery of LAT DNA rectified Th2/Treg imbalance in OVA-induced allergic asthma. LAT-PLC-γ1 interaction contributes to rectification of Th2/Treg imbalance partly via Raf-MEK-ERK and PI3K-AKT-CREB pathways.