Single and 14-day repeated dose inhalation toxicity studies of hexabromocyclododecane in rats
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- 作者：Naining Song ; Lei Li ; Haishan Li ; Wenchao Ai ; Wenping Xie ; Wenlian Yu ; Wei Liu ; Cheng Wang ; Guolin Shen ; Lili Zhou ; Changlei Wei ; Dong Li ; Huiming Chen ; chenhm@aqsiqch.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hexabromocyclododecane ; Acute inhalation toxicity ; Repeated-dose inhalation toxicity ; Head/nose-only inhalation exposure
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：73-81
- 全文大小：4290 K
文摘
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This study determined the acute and potential subchronic toxicities of HBCD in S.D. rats through head/nose-only exposure.
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The inhalation LC50(4 h) for HBCD was higher than 5312 ± 278 mg/m3 for both males and females.
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In the repeated dose inhalation study, the NOAEL for 14-day repeated dose inhalation toxicity study of HBCD was 2000 mg/m3.