Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG
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- 作者：Lingshang Konga ; 1 ; Xiaolong Dua ; 1 ; Nan Hua ; Wendong Lia ; Wenbin Wangb ; Sen Weia ; Hao Zhuanga ; Xiaoqiang Lia ; 563677272@qq.com" class="auth_mail" title="E-mail the corresponding author ; Chenglong Lia ; ning2005@139.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：EPC ; endothelial progenitor cells ; DVT ; deep vein thrombosis ; miRNA ; microRNA ; FASLG ; Fas ligand ; 3&prime ; -UTR ; 3&prime ; -untranslated region ; GFP ; green fluorescent protein ; IVC ; inferior vena cava
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：30-36
- 全文大小：2048 K
文摘
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Differentially expressed let-7e-5p in EPCs from health control and DVT patients
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Let-7e-5p regulates migration and tube formation of EPC.
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FASLG is a validated target of let-7e-5p.
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Let-7e-5p and FASLG functionally regulate EPC function.
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Let-7e-5p increases EPC homing and CD34-positive vessels number.