Lipophilic but not hydrophilic statin functionally inhibit volume-activated chloride channels by inhibiting NADPH oxidase in monocytes
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- 作者：Zhi-jie Fua ; Xue-zhen Zhongb ; Wei-hong Mac ; Wen-dong Zhangd ; zhangwendong_ql@163.com" class="auth_mail" title="E-mail the corresponding author ; Cheng-yao Shid
- 关键词：Volume-activated chloride channel ; Simvastatin ; Pravastatin ; Monocytes ; Reactive oxygen species ; Inflammation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：481
- 期：1-2
- 页码：117-124
- 全文大小：2080 K
文摘
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A hypotonic solution induces volume-activated Cl− channel currents in monocytes.
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Simvastatin regulates volume-activated chloride channels by inhibiting NADPH oxidase.
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Simvastatin decrease hyposmolality induced inflammation by inhibiting NADPH oxidase.