Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification
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- 作者：Ferdinand von Meyenn1 ; vonmeyenn@babraham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Rebecca V. Berrens1 ; Simon Andrews2 ; Fá ; tima Santos1 ; Amanda J. Collier1 ; Felix Krueger2 ; Rodrigo Osorno1 ; Wendy Dean1 ; Peter J. Rugg-Gunn1 ; Wolf Reik1 ; 3 ; 4 ; wolf.reik@babraham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：primordial germ cell ; PGC ; PGC-like cell ; chromatin ; epigenetic resetting ; epigenetic reprogramming ; PGC specification ; DNA methylation ; piRNA ; Piwi-interacting RNA
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：39
- 期：1
- 页码：104-115
- 全文大小：2658 K
文摘
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Defined specification of human in vitro PGCLCs from naive ESCs
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Human and mouse epigenetic germline reprogramming tempo differs significantly
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Demethylation-resistant regions are enriched in TEs and repressive chromatin marks
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Mouse in vitro PGCLCs show expression of transposon-derived piRNAs