Surface biofunctional drug-loaded electrospun fibrous scaffolds for comprehensive repairing hypertrophic scars

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• 作者：Liying Cheng^a ; ¹ ; Xiaoming Sun^a ; ¹ ; Xin Zhao^c ; ¹ ; Lan Wang^b ; Jia Yu^b ; Guoqing Pan^b ; Bin Li^b ; Huilin Yang^b ; Yuguang Zhang^a ; ^{zhangyg18@126.com" class="auth_mail" title="E-mail the corresponding author} ; Wenguo Cui^b ; ^{wgcui80@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Electrospun scaffold ; Poly (dopamine) ; Biofunctionalization ; Drug-loading ; Hypertrophic scar
• 刊名：Biomaterials
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：83
• 期：Complete
• 页码：169-181
• 全文大小：3653 K

文摘

Incorporation of bioactive drugs and biofunctionalization of polyester fibrous scaffolds are essential means to improve their bio-functions and histocompatibility for regenerative medicine. However, it is still a challenge to biofunctionalize such drug carriers via traditional biochemical methods while maintaining their properties without changes in drug activity and loading ratio. Here, we demonstrated a facile approach for biofunctionalization of PLGA fibrous scaffolds with various molecules (i.e., PEG polymer, RGD peptide and bFGF growth factor for cell repellent, adhesion and proliferation, respectively) via mussel-Inspired poly(dopamine) (PDA) coating in aqueous solution. By virtue of the mild and efficient nature of this approach, the drug-loaded PLGA fibers could be easily biofunctionalized and showed negligible effects on the scaffold properties, especially drug activity and loading ratio. Further, in vivo study showed that, a ginsenoside-Rg3-loaded fibrous scaffold functionalized with bFGF growth factor could not only promote the early-stage wound healing in rabbit ear wounds (bio-signal from bFGF), but also inhibit later-stage hypertrophic scars formation (release of Rg3 drug). Therefore, the mussel-inspired method for bio-modification provides a facile and effective strategy to combine drug and bio-function in one system, thus facilitating a synergistic effect of drug-therapy and bio-signal when such biomaterial is used for regenerative medicine.