Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability
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- 作者：Weidong Zeng ; Qi Li ; Tao Wan ; Cui Liu ; Wenhui Pan ; Zushuai Wu ; Guoguang Zhang ; Jingtong Pan ; Mengyao Qin ; Yuanyuan Lin ; Chuanbin Wu ; Yuehong Xu ; lssxyh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AUC ; area under curve ; C6 ; coumarin 6 ; CLSM ; confocal laser scanning microscope ; Cmax ; the peak concentration ; EDAC ; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride ; FK506 ; tacrolimus ; G&prime ; elastic modulus ; G&Prime ; viscous modulus ; HA ; hyaluronic acid ; HPLC ; high performance liquid chromatography ; IS ; internal standard ; MRT ; mean residence time ; NHS ; N-hydroxysuccinimide ; PBS ; phosphate buffer solution ; PBST ; Solution was prepared by 2 ; L ultra-pure water containing 10
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：28-35
- 全文大小：1788 K
文摘
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An ocular delivery system for tacrolimus (FK506) based on a combined strategy of niosomes and mucoadhesive hyaluronic acid (HA), i.e., FK506HA-coated niosomes, was developed.
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HA-coating exhibited enhancement of the adhesion strength and rate of niosomes to mucin by surface plasmon resonance.
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HA-coated niosomes prolonged FK506 precorneal retention, increased its aqueous humor pharmacokinetics, and improved its ophthalmic bioavailability.
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HA-coated niosomes is a promising approach for ocular targeting delivery of FK506.