Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt
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- 作者：Jinfang Zhang2 ; 7 ; Kai Xu1 ; 2 ; 7 ; Pengda Liu2 ; Yan Geng3 ; Bin Wang2 ; 4 ; Wenjian Gan2 ; Jianping Guo2 ; Fei Wu2 ; 6 ; Y. Rebecca Chin2 ; Christian Berrios5 ; Evan C. Lien2 ; Alex Toker2 ; James A. DeCaprio5 ; Piotr Sicinski3 ; Wenyi Wei2 ; wwei2@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：16 June 2016
- 年：2016
- 卷：62
- 期：6
- 页码：929-942
- 全文大小：4717 K
文摘
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Rb, but not p107 or p130, negatively regulates the kinase activity of mTORC2
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Hyper-phosphorylated Rb interacts with Sin1 to block the access of Akt to mTORC2
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Inhibiting Rb phosphorylation leads to elevated Akt-pS473 to confer drug resistance
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A CDK4/6 inhibitor synergizes with an Akt inhibitor in treating Rb-positive cancer cells