Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways
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- 作者：Yingzhuan Zhan ; Rui Liu ; Wenjie Wang ; Jing Li ; Xiaoyan Ou Yang ; Yanmin Zhang ; zhang2008@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Total saponins ; Hepatocellular carcinoma ; Lung cancer ; PI3K/Akt/mTOR ; p38 MAPK
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：39-44
- 全文大小：1383 K
文摘
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RLTS suppressed proliferation and colony formation in lung and liver cancer cells.
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RLTS inhibited the migration of NCI-H460 and SMMC-7721 cells.
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RLTS inhibited PI3K/AKT/mTOR signaling cascades.
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RLTS regulated p38 activation in tumor cells.