Selection and characterization of single-chain recombinant antibodies against infectious haematopoietic necrosis virus from mouse phage display library
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- 作者：Hong Liua ; Xiaocong Zhengb ; Xiujie Shib ; Li Yub ; Peng Jiab ; Jinjin Wangb ; Junqiang Heb ; Wensheng Lanb ; Hong Liub ; liuhong@szciq.gov.cn" class="auth_mail ; Zhixin Wua ; wuzhixin@mail.hzau.edu.cn" class="auth_mail
- 关键词：Phage display ; Single-chain fragment variable antibody ; Infectious haematopoietic necrosis virus
- 刊名：Journal of Virological Methods
- 出版年：1 September 2014
- 年：2014
- 卷：205
- 期：Complete
- 页码：61-67
- 全文大小：1663 K
文摘
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This is the first study about the production and characterization of specific antibody fragments obtained by phage display technology directly against IHNV.
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Six specific soluble scFv antibodies against IHNV were obtained.
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Phage display technology is more convenient for producing monoclonal antibodies than traditional hybridoma technology.