Interaction of titanium dioxide nanoparticles with glucose on young rats after oral administration

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• 作者：Zhangjian Chen ; PhD^a ; Yun Wang ; PhD^a ; ^{wangyun@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Lin Zhuo ; MM^a ; Shi Chen ; MM^a ; Lin Zhao ; PhD^a ; Tian Chen ; PhD^a ; Yang Li ; PhD^a ; Wenxiao Zhang ; MM^a ; Xin Gao ; MM^a ; Ping Li ; PhD^a ; Haifang Wang ; PhD^b ; Guang Jia ; PhD^a ; ^{jiaguangjia@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Combined toxic effects ; Interaction ; Titanium dioxide nanoparticles ; Glucose ; Antagonistic effect
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：11
• 期：7
• 页码：1633-1642
• 全文大小：1859 K

文摘

Titanium dioxide nanoparticles (TiO₂ NPs) have a broad application prospect in replace with TiO₂ used as a food additive, especially used in sweets. Understanding the interaction of TiO₂ NPs with sugar is meaningful for health promotion. We used a young animal model to study the toxicological effect of orally administrated TiO₂ NPs at doses of 0, 2, 10 and 50 mg/kg per day with or without daily consumption of 1.8 g/kg glucose for 30 days and 90 days. The results showed that oral exposure to TiO₂ NPs and TiO₂ NPs + glucose both induced liver, kidney, and heart injuries as well as changes in the count of white and red blood cells in a dose, time and gender-dependent manner. The toxicological interactions between orally-administrated TiO₂ NPs and glucose were evident, but differed among target organs. These results suggest that it is necessary to limit dietary co-exposure to TiO₂ NPs and sugar.

From the Clinical Editor

Nanotechnology has gained entrance in the food industry, with the presence of nanoparticles now in many food items. Despite this increasing trend, the potential toxic effects of these nanoparticles to human remain unknown. In this article, the authors studied titanium dioxide nanoparticles (TiO2 NPs), which are commonly used as food additive, together with glucose. The findings of possible adverse effects on liver, kidney, and heart might point to a rethink of using glucose and TiO2 NPs combination.