Inflammatory responses of stromal fibroblasts to inflammatory epithelial cells are involved in the pathogenesis of bovine mastitis
详细信息 查看全文
- 作者：Wenyao Zhanga ; Xuezhong Lia ; Tong Xua ; Mengru Maa ; Yong Zhanga ; b ; zhangyong1956@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ming-Qing Gaoa ; b ; gaomingqing@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：LPS ; lipopolysaccharide ; LTA ; lipoteichoic acid ; S. aureus ; Staphylococcus aureus ; E. coli ; Escherichia coli ; BMEs ; bovine mammary gland epithelial cells ; BMFs ; bovine mammary stromal fibroblasts ; ECM ; extracellular matrix ; TNF-α ; tumor necrosis factor-alpha ; CCK-8 ; Cell Counting Kit-8 ; IL-6 ; interleukin- 6 ; IL-8 ; interleukin- 8 ; CXCL2 ; Chemokine (C-X-C motif) ligand 2 ; CCL5 ; Chemokine (C-C motif) ligand 5 ; α-SMA ; α-smooth muscle actin ; PDGFR-α ; growth factor receptor α ; PDGFR-β ; growth factor r
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：45-52
- 全文大小：1773 K
文摘
- listitem" id="list_li0005">
- •
Inflammatory BMEs affect the properties of BMFs during mastitis.
- •
BMEs inhibited the proliferation and promoted the migration of BMFs.
- •
BMEs enhanced secretion of inflammatory mediators and deposition of ECM in BMFs.
- •
Changes of the properties of BMFs were mediated by specific signal molecules.