The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study

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• 作者：Guangwei Li ; Ping Zhang ; Jinping Wang ; Edward W Gregg ; Wenying Yang ; Qiuhong Gong ; Hui Li ; Hongliang Li ; Yayun Jiang ; Yali An ; Ying Shuai ; Bo Zhang ; Jingling Zhang ; Theodore J Thompson ; Robert B Gerzo
• 关键词：Reverse Monte Carlo ; Environment dependent interatomic potential ; Amorphous ; Porous ; Carbon ; Silicon
• 刊名：The Lancet
• 出版年：2008
• 出版时间：24 May 2008-30 May 2008
• 年：2008
• 卷：371
• 期：9626
• 页码：1783-1789
• 全文大小：163 K

文摘

Overweight, middle-aged men (n=172) and women (n=350) with impaired glucose tolerance were randomly assigned to intensive lifestyle intervention or control group. After a median of 4 years of active intervention period, participants who were still free of diabetes were further followed up for a median of 3 years, with median total follow-up of 7 years. Diabetes incidence, bodyweight, physical activity, and dietary intakes of fat, saturated fat, and fibre were measured.

Findings

During the total follow-up, the incidence of type 2 diabetes was 4·3 and 7·4 per 100 person-years in the intervention and control group, respectively (log-rank test p=0·0001), indicating 43 % reduction in relative risk. The risk reduction was related to the success in achieving the intervention goals of weight loss, reduced intake of total and saturated fat and increased intake of dietary fibre, and increased physical activity. Beneficial lifestyle changes achieved by participants in the intervention group were maintained after the discontinuation of the intervention, and the corresponding incidence rates during the post-intervention follow-up were 4·6 and 7·2 (p=0·0401), indicating 36 % reduction in relative risk.

Interpretation

Lifestyle intervention in people at high risk for type 2 diabetes resulted in sustained lifestyle changes and a reduction in diabetes incidence, which remained after the individual lifestyle counselling was stopped.