Association of monocyte chemoattractant protein-1 gene 2518A/G polymorphism with diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis
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- 作者：Wei Wang1 ; Miao He1 ; Wenyong Huang ; andyhwyz@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetic retinopathy ; Monocyte chemoattractant protein ; MCP-1 ; Gene polymorphisms ; Meta-analysis
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：40-46
- 全文大小：866 K
文摘
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This meta-analysis included 6 available studies that evaluated the role of MCP-1 gene in presence and progression of DR.
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The G allele and GG genotype of MCP-1 gene increase the susceptible to DR under the homozygous, heterozygous, dominant, recessive, and allelic models.
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The GA genotype of MCP-1 gene was significantly associated with increasing risk of PDR under the heterozygous model.