Effects of HuangKui capsules on glibenclamide pharmacokinetics in rats

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• 作者：Zixiu  ; Liu^a ; Shijia  ; Liu^b ; Ling  ; Zhou^a ; Xiaojun  ; Gao^a ; Wenzheng  ; Ju^b ;   ; ^{wzhju333@163.com.cn} ; Hengshan  ; Tan^b ; Chen  ; Yang^b
• 关键词：HuangKui capsules ; Glibenclamide ; Pharmacokinetics ; LC&ndash ; MS/MS ; Plasma
• 刊名：Journal of Ethnopharmacology
• 出版年：2012
• 出版时间：6 January 2012
• 年：2012
• 卷：139
• 期：1
• 页码：1-5
• 全文大小：471 K

文摘

Ethnopharmacology

The main components of HuangKui capsules?are the total flavonoids extracted from the flowers of Abelmoschus manihot L medic. They have been widely used to treat chronic glomerulonephritis, diabetic nephropathy and nephrotic syndrome. The combination of HuangKui capsules and glibenclamide is a possible therapy for patients with diabetes mellitus and diabetic nephropathy. However, there is no report about effects of HuangKui capsules on the glibenclamide pharmacokinetics till now.

Aim of the study

This study was aimed investigating the effect of HuangKui capsules on pharmacokinetics of glibenclamide in rats.

Material and methods

Eight rats were administered with an oral dose of HuangKui capsules (0.75 g kg^?) once daily for 10 consecutive days. All the rats were administered orally with the glibenclamide (1 mg kg^?) before the first time and after the last time given HuangKui capsules. LC¨CMS/MS was utilized to determine the concentration of glibenclamide in rat plasma and to calculate the corresponding pharmacokinetic parameters. The statistical differences of the two cycles were evaluated by paired-samples t-test.

Results

In the rats treated with HuangKui capsules and glibenclamide, the t_1/2, the time point of maximum plasma concentration (T_max) of glibenclamide increased obviously (p < 0.05) compared with the glibenclamide alone, while maximum plasma concentrations (C_max), area under the plasma concentration-time curve (AUC_(0?i>t)) decreased significantly (p < 0.05). There was no significant difference between other parameters.

Conclusion

HuangKui capsules can reduce the absorption of glibenclamide and accelerate the metabolism of glibenclamide.