- 作者：Werner Hartwig M.D.a ; werner.hartwig@med.uni-heidelberg.de"" rel=""nofollow ; Maike Denneberg M.D.a ; Frank Bergmann M.D.b ; Thilo Hackert M.D.a ; Ulf Hinz M.S.a ; Oliver Strobel M.D.a ; Markus W. Bü ; chler M.D.a ; Jens Werner M.D.a
- 关键词：me=""txt0010"">Pancreasme=""txt0015""> ; Pancreatic cancerme=""txt0020""> ; Surgeryme=""txt0025""> ; Metastasis
- 刊名：The American Journal of Surgery
- 出版年：2011
- 出版时间：July 2011
- 年：2011
- 卷：202
- 期：1
- 页码：23-27
- 全文大小：363 K
BackgroundAcinar cell carcinoma (ACC) of the pancreas is characterized by better long-term survival compared with the more common ductal adenocarcinoma, and prognosis is better in resected compared with nonresected patients. The aim of the present study was to investigate the role of surgery in ACC with limited metastatic disease.Methods
All patients with histologically confirmed ACC treated at the investigators' institution between October 2001 and September 2009 were identified from a prospective database. Clinicopathologic details, perioperative results, and follow-up results were analyzed.
Results
Seventeen patients with nonmetastatic and metastatic ACC were identified. Initially, localized, locoregional, and metastatic disease was present in 5, 7, and 5 patients, respectively. Pancreatic resections were performed in 15 patients. In limited metastatic disease, additional liver resection was performed in 3 patients and omentectomy in 1 patient. In 2 patients, metachronous liver metastases were resected. With a median follow-up period of 36.5 months, overall 1-year, 2-year, and 3-year survival rates were 88 % , 65 % , and 47 % , respectively. Survival of resected patients with metastatic and nonmetastatic disease showed no differences between the 2 groups.
Conclusions
ACC of the pancreas is a relatively rare tumor entity for which resection may result in long-term survival even in limited metastatic disease.