Multi-gram syntheses of four crown ethers using Kp>+p> as templating agent

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• 作者：Hanlie R. Wessels ; Harry W. Gibsonp> ; p>p>hwgibson@vt.edu" class="auth_mail" title="E-mail the corresponding authorp>
• 关键词：Crown ethers ; Templation ; Supramolecular chemistry ; Improved synthesis
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：21 January 2016
• 年：2016
• 卷：72
• 期：3
• 页码：396-399
• 全文大小：325 K

文摘

Dibenzo-30-crown-10 (DB30C10, 1c), dibenzo-24-crown-8 (DB24C8, 1a), 4-carbomethoxydibenzo-24crown-8 (1b) and a new crown ether, 4-carbomethoxydibenzo-30-crown-10 (1d), were synthesized by a simple, high yielding, three-step method. Potassium ions from the highly soluble KPF₆ were employed to template the cyclization step, which resulted in very high isolated yields (80–90%).