Upregulation of neuronal nitric oxide synthase, edema and cell injury following heat stress are reduced by pretreatment with EGB-761 in the rat
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- 作者：Sharma ; H.S. ; Drieu ; K. ; Alm ; P. ; Westman ; J.
- 关键词：Heat stress ; EGB-761 ; Hyperthermia ; Cell injury ; Brain edema ; Nitric oxide ; Nitric oxide synthase ; Anti-oxidants ; Heat exposure
- 刊名：Journal of Thermal Biology
- 出版年：1999
- 出版时间：October, 1999
- 年：1999
- 卷：24
- 期：5-6
- 页码：439-445
- 全文大小：172 K
文摘
Rats exposed to 4 h heat stress (HS) at 38°C exhibited marked upregulation of neuronal nitric oxide synthase (nNOS) in the brain regions exhibiting blood–brain barrier (BBB) breakdown, brain edema and cell damage. Pretreatment with an anti-oxidant compound EGB-761 (an extract of Gingko biloba) administered 50 mg/kg, per os for 5 days, significantly attenuated nNOS expression, BBB disruption, brain edema and cell injury. These results suggest that EGB-761 is neuroprotective in heat stress and this effect of the compound is related with the inhibition of NOS expression, not reported earlier.