Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy
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- 作者：Cordula Grü ; ttner ; Knut Mü ; ller ; Joachim Teller ; Fritz Westphal ; Allan Foreman ; Robert Ivkov
- 关键词：Magnetic nanoparticle ; Hyperthermia ; Antibody conjugation ; Specific power absorption rate ; Cancer therapy ; Alternating magnetic field
- 刊名：Journal of Magnetism and Magnetic Materials
- 出版年：2007
- 出版时间：April 2007
- 年：2007
- 卷：311
- 期：1
- 页码：181-186
- 全文大小：272 K
文摘
Bionized nanoferrite (BNF) particles with high specific power absorption rates were synthesized in the size range of 20–100 nm by high-pressure homogenization for targeted cancer therapy with alternating magnetic fields. Several strategies were used to conjugate antibodies to the BNF particles. These strategies were compared using an immunoassay to find optimal conditions to reach a high immunoreactivity of the final antibody–particle conjugate.