Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers
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- 作者：Viktó ; ria Kormosa ; b ; Lá ; szló ; Gá ; spá ; ra ; Lá ; szló ; Á ; . Ková ; csa ; Jó ; zsef Farkasa ; Tamá ; s Gasznera ; Valé ; r Csernusa ; Andrá ; s Baloghc ; Hitoshi Hashimotod ; e ; f ; Dó ; ra Reglődia ; h ; Zsuzsanna Helyesb ; g ; h ; Balá ; zs Gasznera ; balazs.b.gaszner@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5HT ; serotonin ; ANOVA ; analysis of variance ; BST ; bed nucleus of the stria terminalis ; BLA ; basolateral nucleus of amygdala ; CA1 ; cornu Ammonis 1 region of the hippocampal formation ; CA3 ; cornu Ammonis 3 region of the hippocampal formation ; CeA ; central nucleus of amygdala ; CORT ; corticosterone ; CRF ; corticotropin-releasing factor ; cpEW ; centrally projecting Edinger-Westphal nucleus ; CVMS ; chronic variable mild stress ; DAB ; 3 ; 3&prime ; diamino-benzidine ; DG ; dentate gyrus ; dLS ; dorsal lateral sep
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：330
- 期：Complete
- 页码：335-358
- 全文大小：3972 K
文摘
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Lack of PACAP is associated with reduced HPA axis activity in CVMS.
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The FosB expression is blunted in the CeA, dmBST, ovBST, vBST, CA1, pPVN, DR in PACAP KO mice.
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CRF neurons in the ovBST and Ucn1 cells of the cpEW do not respond to CVMS in PACAP KO mice.
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PACAP KO mice show increased serotonin content in DR neurons.
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Lack of PACAP influences the stress response in a brain area in a specific manner.