Post-contrast enhancement as a clinical indicator of prognosis in patients with anaplastic astrocytoma
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- 作者：Elie Matar ; Raymond J. Cook ; Adam R. Fowler ; Michael T. Biggs ; Nicholas S. Little ; Helen R. Wheeler ; Bruce G. Robinson ; Kerrie L. McDonald
- 关键词：Anaplastic astrocytoma ; Enhancing lesions ; Gadolinium contrast ; MRI ; Non-enhancing lesions ; Prognosis
- 刊名：Journal of Clinical Neuroscience
- 出版年：2010
- 出版时间：August 2010
- 年：2010
- 卷：17
- 期：8
- 页码：993-996
- 全文大小：357 K
文摘
Diagnosis of an anaplastic astrocytoma (World Health Organization grade III) is associated with a highly variable prognosis. The identification of clinical markers that allow a more careful delineation of this prognostic spectrum is urgently needed. In this study, we analysed 48 patients with a histological diagnosis of anaplastic astrocytoma and found peritumoral post-gadolinium contrast enhancement to be a clear prognostic marker of poor prognosis. Multivariate analysis also confirmed surgery type, Karnofsky Performance Status score (<70) and increasing age as independent adverse predictors of survival. The survival differences observed in the enhancing and non-enhancing lesions in patients diagnosed with anaplastic astrocytoma supports the existence of a broad anaplastic spectrum of disease, with enhancement being a clinical marker of tumour progression along this spectrum.