Characterisation of beam focus quality in biomedical nuclear microscopy: A Fourier optics approach

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• 作者：Harry J. Whitlow ; Minqin Ren ; Jeroen A. van Kan ; Thomas Osipowicz ; Frank Watt
• 关键词：Nuclear microscopy ; Autocorrelation function ; STIM ; Quadrupole lens ; Biomedical imaging
• 刊名：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
• 出版年：2009
• 出版时间：15 June 2009
• 年：2009
• 卷：267
• 期：12-13
• 页码：2149-2152
• 全文大小：537 K

文摘

The central peak widths of the 2D-autocorrelation function have been investigated as a Figure of Merit (FoM) of focus quality in nuclear microscopy using a quadrupole triplet lens system. The beam focus could be reliably characterised for direct scanning transmission ion microscopy (direct-STIM) images obtained with fluences as small as 5.8×10⁹ ions cm^-2 which colocalisation tests showed did not introduce significant beam-induced changes in the cells.