Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain
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- 作者：Tristan I. Croll1 ; Brian J. Smith2 ; Mai B. Margetts3 ; Jonathan Whittaker4 ; Michael A. Weiss4 ; 5 ; Colin W. Ward3 ; Michael C. Lawrence3 ; 6 ; lawrence@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：24
- 期：3
- 页码：469-476
- 全文大小：2456 K
文摘
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The structure of the insulin receptor ectodomain is improved to 3.3 Å resolution
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The structure reveals new features within the receptor insert domain
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The structure corrects errors in the first and third fibronectin type III domains
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A new low-resolution crystallographic model-building strategy, iMDFF, is presented