Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation

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• 作者：Simon J. Pridmore ; Paul A. Slatford ; James E. Taylor ; Michael K. Whittlesey ; Jonathan M.J. Williams
• 关键词：Ruthenium ; Catalysis ; Isomerisation ; Furans ; Pyrroles
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：31 October 2009
• 年：2009
• 卷：65
• 期：44
• 页码：8981-8986
• 全文大小：331 K

文摘

Alkyne-1,4-diols are readily available substrates which are isomerised to 1,4-diketones using Ru(PPh₃)₃(CO)H₂/xantphos as a catalyst. In situ cyclisation into furans, pyrroles and pyridazines has been achieved under suitable conditions.