Secondary metabolites and their biological activities in Indonesian soft coral of the genus Lobophytum

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• 作者：Masteria Yunovilsa Putra¹ ; ^{mast001@lipi.go.id" class="auth_mail" title="E-mail the corresponding author} ; Tutik Murniasih¹ ; Respati Tri Swasono² ; Joko Tri Wibowo¹ ; Annissa Nur Cahya Saputri² ; Meilia Rahma Widhiana² ; Irma Shita Arlyza¹
• 关键词：Ocean ; Indonesia ; Natural products ; Biological activities
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：6
• 期：11
• 页码：909-913
• 全文大小：670 K

文摘

To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n-hexane, ethyl acetate, n-butanol, and aqueous fractions from a crude extract of Lobophytum sp.

Methods

This organism was collected from the Selayar Islands (South Sulawesi). The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial activity.

Results

It was found that the ethyl acetate, n-butanol and aqueous fractions exhibited heme polymerization inhibitory activity with IC₅₀ values of 11.7, 14.3 and 12.0 μg/mL, respectively, while the n-butanol fraction showed moderate antioxidant activity and cytotoxicity with IC₅₀ values of 150.00 and 92.74 μg/mL, respectively.

Conclusions

This study provides information on antioxidant, antibacterial and antimalarial activities as well as the cytotoxicity of all fractions from the crude extract of Lobophytum sp. This is a new report of antimalarial substances derived from Lobophytum sp.