Reduced-Intensity Conditioning with Fludarabine, Cyclophosphamide, and Rituximab Is Associated with Improved Outcomes Compared with Fludarabine and Busulfan after Allogeneic Stem Cell Transplantation for B Cell Malignancies
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- 作者：Vanessa E. Kennedy1 ; vanessa.e.kennedy@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Bipin N. Savani1 ; 2 ; 3 ; John P. Greer1 ; 3 ; Adetola A. Kassim1 ; 3 ; Brian G. Engelhardt1 ; 3 ; Stacey A. Goodman1 ; 2 ; 3 ; Salyka Sengsayadeth1 ; 3 ; Wichai Chinratanalab1 ; 2 ; 3 ; Madan Jagasia1 ; 3
- 关键词：Reduced-intensity conditioning ; Conditioning regimen ; Rituximab ; Chronic graft-versus-host disease
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：22
- 期：10
- 页码：1801-1807
- 全文大小：379 K
文摘
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Two sequential transplant strategies were retrospectively compared.
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These strategies were fludarabine/cyclophosphamide/rituximab + tacrolimus/methotrexate versus fludarabine/busulfan + tacrolimus/MMF.
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FCR had improved overall survival compared with FluBu.
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FCR had decreased chronic GVHD compared with FluBu.