The important role of protamine in spermatogenesis and quality of sperm: A mini review

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• 作者：Muslim Akmal¹ ; ^{muslim_akmal70@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Aulanni'am Aulanni'am² ; M. Aris Widodo³ ; Sutiman B. Sumitro⁴ ; Basuki B. Purnomo³ ; Widodo⁴ ; ^{widodo@ub.ac.id" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sperm ; Inhibin B ; Protamine ; Spermatogenesis ; Male fertility
• 刊名：Asian Pacific Journal of Reproduction
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：5
• 期：5
• 页码：357-360
• 全文大小：596 K

文摘

To prove that the decrease in the expression of protamine 2 affects the fertilization ability and the number of child production.

Methods

During the development stage of elongating spermatids, human spermatozoa chromatin undergoes a complex transition where histone is extensively replaced by protamine. Histone substitution by protamine 1 and 2 plays a significant role in condensing chromatin required to induce the quality of potent spermatozoa. The substitution also has a key role in protecting spermatozoa from effects of free radicals which can degrade the spermatozoa quality.

Results

The results revealed that protamine deficiency instigated a severe disruption of spermatogenesis affecting male infertility. In addition, the protamine expression disorder caused a decrease in number, motility, and morphology of spermatozoa.

Conclusion

Our results of a study in mice confirmed that inhibin B injection caused a reduction in the expression of protamine 2 in cauda epididymis. It has implications in the decrease of motility, concentration, and spermatozoa viability so that it affects the fertilization ability and the number of child production.