Promoting intestinal adaptation by nutrition and medication

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• 作者：E.G. Neelis^a ; ^{e.neelis@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} ; J.F. Olieman ; PhD^b ; ^c ; ¹ ; ^{j.olieman@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} ; J.M. Hulst ; MD ; PhD^a ; ² ; ^{j.hulst@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} ; B.A.E. de Koning ; MD ; PhD^a ; ³ ; ^{b.dekoning@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} ; R.M.H. Wijnen ; MD ; PhD^b ; ⁴ ; ^{r.wijnen@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} ; E.H.H.M. Rings ; MD ; PhD^a ; ^d ; ⁵ ; ^{e.rings@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Enteral nutrition ; Growth factors ; Intestinal adaptation ; Intestinal failure ; Parenteral nutrition ; Short bowel syndrome
• 刊名：Best Practice & Research Clinical Gastroenterology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：30
• 期：2
• 页码：249-261
• 全文大小：335 K

文摘

The ultimate goal in the treatment of short bowel syndrome is to wean patients off parenteral nutrition, by promoting intestinal adaptation. Intestinal adaptation is the natural compensatory process that occurs after small bowel resection. Stimulating the remaining bowel with enteral nutrition can enhance this process. Additionally, medication can be used to either reduce factors that complicate the adaptation process or to stimulate intestinal adaptation, such as antisecretory drugs and several growth factors. The aim of this review was to provide an overview of the best nutritional strategies and medication that best promote intestinal adaptation.