Impact of intraprocedural thrombotic events on short- and long-term outcomes following percutaneous coronary intervention. Evidence from a meta-analysis

详细信息    查看全文

• 作者：Ramez Nairooz^a ; ^{ramez.nairooz@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Dmitriy N. Feldman^b ; Yogita Rochlani^c ; Wilbert S. Aronow^d ; Partha Sardar^e ; Debabrata Mukherjee^f ; Srihari S. Naidu^g ; Pranav Patel^h
• 关键词：PCI ; Intraprocedural thrombotic events ; No reflow ; Distal embolization
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：1 January 2016
• 年：2016
• 卷：202
• 期：Complete
• 页码：469-476
• 全文大小：1204 K

文摘

Data regarding the effects of intraprocedural thrombotic events (IPTE) are scarce. Hence we aim to perform a meta-analysis to examine the outcomes of IPTE compared to non-IPTE during PCI.

absSec_2">Methods

We performed a literature search of all published full-length articles of studies that reported data on patients with IPTE compared with non-IPTE during PCI. We calculated odd ratios via random effects model.

absSec_3">Results

A total of 26,697 patients, of which 1572 patients had IPTE, were included in this analysis. In-hospital, IPTE was associated with higher mortality (odds ratio (OR) 5.36, 95% confidence interval (CI) [2.31, 12.41]; p < 0.0001), myocardial infarction (MI) and major bleeding compared to non-IPTE. At 30 days, IPTE was also associated with higher mortality (OR 4.57, 95% CI [2.43, 8.60]; p < 0.0001), MI, repeat revascularization, stent thrombosis and major bleeding compared to non-IPTE group. IPTE was also associated with higher long-term mortality (OR 2.19, 95% CI [1.35, 3.53]; p = 0.001). Among IPTE patients, intraprocedural stent thrombosis was associated with greater odds of MI compared to both no reflow and distal embolization events.

absSec_4">Conclusion

IPTE during PCI is associated with more adverse ischemic events, including mortality, during the index hospitalization, at 30 days and long-term.