Secondhand Smoke Exposure and Illness Severity among Children Hospitalized with Pneumonia

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• 作者：Anna Ahn ; MD¹ ; ² ; Kathryn M. Edwards ; MD¹ ; ² ; Carlos G. Grijalva ; MD ; MPH³ ; Wesley H. Self ; MD ; MPH⁴ ; Yuwei Zhu ; MD ; MS⁵ ; James D. Chappell ; MD ; PhD² ; ⁶ ; Sandra R. Arnold ; MD⁷ ; Jonathan A. McCullers ; MD⁷ ; ⁸ ; Krow Ampofo ; MD⁹ ; Andrew T. Pavia ; MD⁹ ; Anna M. Bramley ; MPH¹⁰ ; Seema Jain ; MD¹⁰ ; Derek J. Williams ; MD ; MPH¹ ; ² ; ^{derek.williams@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：aHR ; Adjusted hazard ratio ; CAP ; Community-acquired pneumonia ; EPIC ; Etiology of Pneumonia in the Community ; SHS ; Secondhand smoke
• 刊名：The Journal of Pediatrics
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：167
• 期：4
• 页码：869-874.e1
• 全文大小：568 K

文摘

To assess the relationship between secondhand smoke (SHS) exposure and disease severity among children hospitalized with community-acquired pneumonia (CAP).

Study design

Children hospitalized with clinical and radiographic CAP were enrolled between January 1, 2010, and June 30, 2012 at 3 hospitals in Tennessee and Utah as part of the Centers for Disease Control and Prevention's Etiology of Pneumonia in the Community study. Household SHS exposure was defined based on the number of smokers in the child's home. Outcomes included hospital length of stay, intensive care unit admission, and mechanical ventilation. Proportional hazards and logistic regression models were used to assess associations between SHS exposure and outcomes. All models were adjusted for age, sex, race/ethnicity, household education level, government insurance, comorbidities, enrollment site, year, and season.

Results

Of the 2219 children included in the study, SHS exposure was reported in 785 (35.4%), including 325 (14.8%) with ≥2 smokers in the home. Compared with nonexposed children, the children exposed to ≥2 smokers had longer length of stay (median, 70.4 hours vs 64.4 hours; adjusted hazard ratio, 0.85; 95% CI, 0.75-0.97) and were more likely to receive intensive care (25.2% vs 20.9%; aOR, 1.44; 95% CI, 1.05-1.96), but not mechanical ventilation. Outcomes in children exposed to only 1 household smoker were similar to those in nonexposed children.

Conclusion

Children hospitalized with CAP from households with ≥2 smokers had a longer length of stay and were more likely to require intensive care compared with children from households with no smokers, suggesting that they experienced greater pneumonia severity.