C-KIT Receptor Maintains Cardiac Function in Aging Mice Post MI

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• 作者：Brian R. Barrows ; Agnes Azimzadeh ; Stacey L. McCulle ; Gloria Vives-Rodriguez ; Stacey L. McCulle ; C. William Balke ; Richard N. Pierson III ; Stephen S. Gottlieb ; Frances L. Johnson ; Meredith Bond
• 关键词：MAP kinase ; Hypertension ; Cardiac remodeling ; Heart failure
• 刊名：Journal of Cardiac Failure
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：12
• 期：6, Supplement 1
• 页码：S41
• 全文大小：78 K

文摘

Angiotensin II type 1 receptor blocker L-158,809 (ARB) induces reverse left ventricular (LV) remodeling in spontaneously hypertensive heart failure (SHHF) rats. However, the signaling mechanism that mediates ARB-induced reverse LV remodeling remains unclear. The present study was to determine if changes in mitogen-activated protein kinase (MAPK, including ERK, JNK, and p38) signaling correlate with ARB-elicited reversal of cardiac hypertrophy in SHHF rats.

class=""h4"">Methods and Results

In 1 set of experiments, 5-month-old lean female SHHF rats were treated with L-158,809 (ARB) or the vasodilator hydralazine (HYD) for 1 month, respectively. In a second set of experiments, 5-month-old SHHF rats were treated with ARB for 6 months or 1 month and then with HYD for 5 months. Either ARB or HYD normalized left ventricular end systolic pressure in SHHF rats relative to normotensive control Wistar Furth (WF) rats at both 6 and 11 months of age, but only ARB reduced heart-to-body weight ratio in SHHF rats to control level. Western blot analysis showed that cardiac p38 MAPK activity was markedly increased in 6-month-old SHHF rats, but dramatically reduced in 11-month-old SHHF rats compared with WF rats, as indicated by the levels of phosphorylated form of p38. The alterations in p38 activity were completely reversed by ARB treatment but not by HYD treatment.

class=""h4"">Conclusion

ARB restored normal cardiac p38 activity, which coincided with ARB-induced reverse LV remodeling in SHHF rats, suggesting a strong correlation between p38 signaling and cardiac remodeling.