Opportunities for improving animal welfare in rodent models of epilepsy and seizures
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- 作者：Katie Lidstera ; 1 ; katie.lidster@nc3rs.org.uk" class="auth_mail" title="E-mail the corresponding author ; John G. Jefferysb ; 1 ; Ingmar Blü ; mckec ; 1 ; Vincenzo Crunellid ; 1 ; Paul Flecknelle ; 1 ; Bruno G. Frenguellif ; 1 ; William P. Grayg ; 1 ; Rafal Kaminskih ; 1 ; Asla Pitkä ; neni ; 1 ; Ian Raganj ; 1 ; Mala Shahk ; 1 ; Michele Simonatol ; 1 ; Andrew Trevelyanm ; 1 ; Holger Volkn ; 1 ; Matthew Walkero ; 1 ; Neil Yatesp ; 1 ; Mark J. Prescotta ; 1
- 关键词：3Rs ; Animal model ; Epilepsy ; Mouse ; Rat ; Refinement ; Seizure
- 刊名：Journal of Neuroscience Methods
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：260
- 期：Complete
- 页码：2-25
- 全文大小：2269 K
文摘
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Report of an expert Working Group to identify opportunities for refining rodent models of epilepsy.
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Based upon a survey of epilepsy community, literature review and expert opinion.
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Background information and recommendations provided to improve animal welfare.
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Practical guidance on refinement opportunities (e.g. induction, recordings, perioperative care).