Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
详细信息 查看全文
- 作者：Sarah K. Denny1 ; 10 ; Dian Yang2 ; 10 ; Chen-Hua Chuang3 ; Jennifer J. Brady3 ; Jing Shan Lim2 ; Barbara M. Grü ; ner3 ; Shin-Heng Chiou3 ; Alicia N. Schep3 ; Jessika Baral3 ; Cé ; cile Hamard7 ; Martine Antoine7 ; Marie Wislez7 ; Christina S. Kong4 ; Andrew J. Connolly4 ; Kwon-Sik Park8 ; Julien Sage2 ; 3 ; 5 ; 6 ; 11 ; William J. Greenleaf1 ; 3 ; 9 ; 11 ; wjg@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Monte M. Winslow2 ; 3 ; 4 ; 5 ; 11 ; mwinslow@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：14 July 2016
- 年：2016
- 卷：166
- 期：2
- 页码：328-342
- 全文大小：5277 K
文摘
- •
SCLC metastases have profound chromatin changes compared to primary tumors
- •
Nfib drives an increase of chromatin accessibility at distal regulatory elements
- •
Nfib is necessary and sufficient for metastatic ability in vivo
- •
Nfib co-opts pro-metastatic neuronal gene expression programs