Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality
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- 作者：Rebecca I. Clark1 ; 6 ; rebecca.clark2@durham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Anna Salazar1 ; Ryuichi Yamada2 ; Sorel Fitz-Gibbon3 ; 4 ; Marco Morselli3 ; Jeanette Alcaraz1 ; Anil Rana1 ; Michael Rera1 ; 7 ; Matteo Pellegrini3 ; 4 ; William W. Ja2 ; David W. Walker1 ; 5 ; davidwalker@ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：8 September 2015
- 年：2015
- 卷：12
- 期：10
- 页码：1656-1667
- 全文大小：3556 K
文摘
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Age-related dysbiosis in Drosophila is characterized by Gammaproteobacteria expansion
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Dysbiosis predicts age-onset intestinal barrier dysfunction and rapid health decline
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Age-related dysbiosis drives changes in excretory function
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Loss of commensal control following intestinal barrier dysfunction drives mortality