Bacterial Vesicle Secretion and the Evolutionary Origin of the Eukaryotic Endomembrane System

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• 作者：Sven B. Gould¹ ; ^{gould@hhu.de" class="auth_mail" title="E-mail the corresponding author} ; Sriram G. Garg¹ ; William F. Martin¹ ; ^{bill@hhu.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：endosymbiosis ; bacterial vesicle secretion ; endomembrane system ; eukaryote origin ; endoplasmic reticulum ; nucleus
• 刊名：Trends in Microbiology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：24
• 期：7
• 页码：525-534
• 全文大小：2979 K

文摘

Eukaryotes possess an elaborate rong class="boldFont">endomembrane systemrong> with endoplasmic reticulum, nucleus, Golgi, rong class="boldFont">lysosomesrong>, rong class="boldFont">peroxisomesrong>, rong class="boldFont">autophagosomesrong>, and dynamic vesicle traffic. Theories addressing the evolutionary origin of eukaryotic endomembranes have overlooked the outer membrane vesicles (OMVs) that bacteria, archaea, and mitochondria secrete into their surroundings. We propose that the eukaryotic endomembrane system originated from bacterial OMVs released by the mitochondrial ancestor within the cytosol of its archaeal host at eukaryote origin. Confined within the host's cytosol, OMVs accumulated naturally, fusing either with each other or with the host's plasma membrane. This matched the host's archaeal secretory pathway for cotranslational protein insertion with outward bound mitochondrial-derived vesicles consisting of rong class="boldFont">bacterial lipidsrong>, forging a primordial, secretory endoplasmic reticulum as the cornerstone of the eukaryotic endomembrane system.

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