Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein

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• 作者：Gladys J. Keitany¹ ; Karen S. Kim¹ ; Akshay T. Krishnamurty¹ ; Brian D. Hondowicz¹ ; William O. Hahn¹ ; Nicholas Dambrauskas² ; D. Noah Sather² ; Ashley M. Vaughan² ; Stefan H.I. Kappe² ; Marion Pepper¹ ; ³ ; ^{mpepper@uw.edu}
• 关键词：malaria ; plasmodium ; memory B cells ; attenuated parasites ; vaccines ; antibodies ; humoral immunity ; antigen specific B cells
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3193-3205
• 全文大小：3307 K
• 卷排序：17

文摘

Malaria B cell reagents are utilized to study B cell differentiation and function Blood stage infection inhibits antibody responses to the pre-erythrocytic antigen, CSP CSP-specific GC and memory B cells are impaired after malaria blood stage infection Altered lymphoid structure, cytokines, and chemokines are associated with defective pre-erythrocytic immunity