Randomized double-blind comparison of cognitive and EEG effects of lacosamide and carbamazepine
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- 作者：Kimford J. Meadora ; kmeador@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; David W. Loringb ; c ; dloring@emory.edu" class="auth_mail" title="E-mail the corresponding author ; Alan Boydd ; aboyd@cnsvs.com" class="auth_mail" title="E-mail the corresponding author ; Javier Echauze ; echauz@ieee.org" class="auth_mail" title="E-mail the corresponding author ; Suzette LaRocheb ; 1 ; Suzette.LaRoche@msj.org" class="auth_mail" title="E-mail the corresponding author ; Naymee Velez-Ruizb ; 2 ; nxv146@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; Pearce Korbf ; pearce.korb@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author ; William Byrnesg ; Bill.Byrnes@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Deanne Dilleyg ; Deanne.Dilley@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Simon Borghsh ; Simon.Borghs@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Marc De Backeri ; Marc.DeBacker@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Tyler Storyj ; 3 ; TylerJStory@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Peter Dedekeni ; Peter.Dedeken@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Elizabeth Websterg ; Elizabeth.Webster@ucb.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AEDs ; antiepileptic drugs ; LCM ; lacosamide ; CBZ-IR ; carbamazepine immediate-release ; EEG ; electroencephalogram ; AEs ; adverse events ; C-SSRS ; Columbia-Suicide Severity Rating Scale ; MCG ; Medical College of Georgia paragraph memory ; SDMT ; Symbol Digit Modalities Test ; POMS ; Profile of Mood States ; ABNAS ; A-B Neuropsychological Assessment Schedule ; TEAEs ; treatment-emergent AEs
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：267-275
- 全文大小：590 K
文摘
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A randomized, double-blind, crossover study in healthy subjects.
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Compared neuropsychological and EEG effects of lacosamide and carbamazepine.
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Carbamazepine also worse for composite EEG score and drug-related adverse events.
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Lacosamide exhibits a favorable cognitive profile compared to carbamazepine.