Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus

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• 作者：Wallaya Phongphaew^a ; Shintaro Kobayashi^a ; ^b ; Michihito Sasaki^a ; Michael Carr^c ; ^d ; William W. Hall^c ; ^e ; ^f ; Yasuko Orba^a ; Hirofumi Sawa^a ; ^c ; ^f ; ^{h-sawa@czc.hokudai.ac.jp}
• 关键词：VCP ; WNV replication ; Early steps ; Genome replication
• 刊名：Virus Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：114-123
• 全文大小：1996 K
• 卷排序：228

文摘

Inhibition of VCP by chemical inhibitors decreased WNV infection in a dose-dependent manner. Knockdown of endogenous VCP level using siRNA suppressed WNV infection. Depletion of VCP levels suppressed WNV infection at the early stages of WNV replication cycle. Depletion of VCP levels lowered nascent WNV genomic RNA. VCP participates in early stages and viral genomic RNA replication.