An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter
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- 作者：Yongliang Huo1 ; Timothy Su2 ; Qiuyin Cai2 ; Ian G. Macara1 ; ian.g.macara@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：7 June 2016
- 年：2016
- 卷：15
- 期：10
- 页码：2089-2096
- 全文大小：3148 K
文摘
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A physiological gain-of-function screen for breast cancer genes is described
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High levels of the transcription factor GTF2IRD1 promote breast cancer development in mice
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GTF2IRD1 promotes tumor growth by regulating downstream genes TGFβR2 and BMPR1b
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GTF2IRD1 correlates clinically with high tumor grades and poor prognosis