- 作者：Stefan Toggweiler ; MD?/sup> ; Ronen Gurvitch ; MBBS?/sup> ; Jonathon Leipsic ; MD&dagger ; ; David A. Wood ; MD?/sup> ; Alexander B. Willson ; MBBS?/sup> ; Ronald K. Binder ; MD?/sup> ; Anson Cheung ; MD&Dagger ; ; Jian Ye ; MD&Dagger ; ; John G. Webb ; MD?/sup> ; john.webb@vch.ca
- 关键词：aortic valve ; complications ; vascular
- 刊名：Journal of the American College of Cardiology
- 出版年：2012
- 出版时间：10 January, 2012
- 年：2012
- 卷：59
- 期：2
- 页码：113-118
- 全文大小：874 K
Objectives
The aim of this study was to evaluate vascular complications in a consecutive patient population undergoing transfemoral percutaneous aortic valve replacement (PAVR) applying current Valve Academic Research Consortium definitions.Background
Vascular complications have been the major cause of mortality and morbidity associated with PAVR. Both open surgical and fully percutaneous access site strategies have been advocated.
Methods
All patients undergoing transfemoral PAVR during fiscal years 2009 and 2010 were prospectively evaluated at baseline, after the procedure, and at 30 days.
Results
PAVR was performed in 137 consecutive patients. All but 1 patient underwent planned arteriotomy closure using a percutaneous pre-closure technique. Smaller sheaths, rigorous angiographic and computed tomographic screening and patient selection, and percutaneous vascular repair techniques were increasingly used over this period. From 2009 to 2010, major vascular complications decreased from 8 % to 1 % (p = 0.06), minor vascular complications decreased from 24 % to 8 % (p < 0.01), major bleeds fell from 14 % to 1 % (p < 0.01), and unplanned surgery decreased from 28 % to 2 % (p < 0.01). A minimal artery diameter smaller than the external sheath diameter, moderate or severe calcification, and peripheral vascular disease were associated with higher vascular complication rates.
Conclusions
Vascular complications occur more often if the minimal artery diameter is smaller than the external sheath diameter, in the presence of moderate or severe calcification, and in patients with peripheral vascular disease. With careful patient selection, advanced interventional techniques, and a fully percutaneous procedure, marked reductions in vascular and bleeding complications can be achieved.