Correlation of Pain and Fluoride Concentration in Allogeneic Hematopoietic Stem Cell Transplant Recipients on Voriconazole
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- 作者：Megan R. Barajas1 ; Kristen B. McCullough2 ; Julianna A. Merten2 ; merten.julianna@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Ross A. Dierkhising3 ; Gabriel T. Bartoo2 ; Shahrukh K. Hashmi4 ; William J. Hogan4 ; Mark R. Litzow4 ; Mrinal M. Patnaik4 ; John W. Wilson5 ; Robert C. Wolf2 ; Robert A. Wermers6
- 关键词：Fluoride ; Voriconazole ; Hematopoietic stem cell transplantation ; Pain ; Musculoskeletal pain
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：22
- 期：3
- 页码：579-583
- 全文大小：177 K
文摘
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Thirty-two of 242 allogeneic hematopoietic stem cell transplantation patients had a fluoride level measured because of pain.
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After 1 year and 2 years, 15.3% and 35.7% of patients, respectively, had an elevated fluoride level.
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Serum creatinine, estimated glomerular filtration rate, alkaline phosphatase, and voriconazole concentration did not predict for fluoride excess and associated pain.
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After voriconazole discontinuation, pain resolved (31.8%) or improved (37%) in most patients.