Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau

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• 作者：Michael Deuschle ; Claudia Schilling ; F. Markus Leweke ; Frank Enning ; Thomas Pollm盲cher ; Hermann Esselmann ; Jens Wiltfang ; Lutz Fr枚lich ; Isabella Heuser
• 关键词：Depression ; Alzheimer's disease ; Orexin ; Hypocretin ; A尾 ; Tau protein
• 刊名：Neuroscience Letters
• 出版年：21 February, 2014
• 年：2014
• 卷：561
• 期：Complete
• 页码：41-45
• 全文大小：492 K

文摘

It has been suggested that sleep-wake regulation as well as hypocretins play a role in the pathophysiology of Alzheimer's disease. We analyzed A尾₄₀, A尾₄₂, Tau protein, phosphorylated Tau (pTau) protein as well as hypocretin-1 concentrations in the CSF of a detection sample of 10 patients with Alzheimer's disease (AD) as well as 10 age- and gender-matched patients with major depression as a comparison group of different pathology. In order to replicate the findings, we used a confirmation sample of 17 AD patients and 8 patients with major depression. We found hypocretin-1 concentrations in CSF not to differ between patients with depression and AD. However, hypocretin-1 was significantly related to Tau (r = 0.463, p < 0.001) and pTau (r = 0.630, p < 0.0001). These effects were more pronounced in depressed patients when compared to AD patients. We conclude that hypocretin-1 may play a role in the metabolism of Tau proteins across different diagnostic entities including AD. It has to be determined whether there is a causal relationship between hypocretin-1 and Tau as well as pTau.