Race and Survival Following Brachytherapy-Based Treatment for Men With Localized or Locally Advanced Adenocarcinoma of the Prostate

详细信息    查看全文

• 作者：Karen M. Winkfield M.D. ; Ph.D.^&lowast ; ;   ; ^&dagger ; ;   ; ^{kwinkfield@partners.org} ; Ming-Hui Chen Ph.D.^&Dagger ; ; Daniel E. Dosoretz M.D.^¶ ; ; Sharon A. Salenius M.P.H.^¶ ; ; Michael Katin M.D.^¶ ; ; Rudi Ross B.S.^¶ ; ; Anthony V. D’ ; Amico M.D. ; Ph.D.^§ ;
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2011
• 出版时间：15 November 2011
• 年：2011
• 卷：81
• 期：4
• 页码：e345-e350
• 全文大小：205 K

文摘

Purpose

We investigated whether race was associated with risk of death following brachytherapy-based treatment for localized prostate cancer, adjusting for age, cardiovascular comorbidity, treatment, and established prostate cancer prognostic factors.

Methods

The study cohort was composed of 5,360 men with clinical stage T1-3N0M0 prostate cancer who underwent brachytherapy-based treatment at 20 centers within the 21st Century Oncology consortium. Cox regression multivariable analysis was used to evaluate the risk of death in African-American and Hispanic men compared to that in Caucasian men, adjusting for age, pretreatment prostate-specific antigen (PSA) level, Gleason score, clinical T stage, year and type of treatment, median income, and cardiovascular comorbidities.

Results

After a median follow-up of 3 years, there were 673 deaths. African-American and Hispanic races were significantly associated with an increased risk of all-cause mortality (ACM) (adjusted hazard ratio, 1.77 and 1.79; 95 % confidence intervals, 1.3?.5 and 1.2?.7; p < 0.001 and p?= 0.005, respectively). Other factors significantly associated with an increased risk of death included age (p < 0.001), Gleason score of 8 to 10 (p?= 0.04), year of brachytherapy (p < 0.001), and history of myocardial infarction treated with stent or coronary artery bypass graft (p < 0.001).

Conclusions

After adjustment for prostate cancer prognostic factors, age, income level, and revascularized cardiovascular comorbidities, African-American and Hispanic races were associated with higher ACM in men with prostate cancer. Additional causative factors need to be identified.