Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure

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• 作者：Wendy J. Watkins ; Alex ; ra J. Umbers ; Kathryn J. Woad ; Sarah E. Harris ; Ingrid M. Winship ; Ksenija Gersak ; Andrew N. Shelling
• 刊名：Fertility and Sterility
• 出版年：2006
• 出版时间：November 2006
• 年：2006
• 卷：86
• 期：5
• 页码：1518-1521
• 全文大小：76 K

文摘

FOXO3A and FOXO1A are excellent candidate genes for the development of premature ovarian failure and have not been analyzed previously in POF patients. Potentially causal mutations in FOXO3A (2/90; 2.2 % ) and FOXO1A (1/90; 1.1 % ) were identified in POF patients; however, the pathological role of these mutations will be determined only by screening increased numbers of patients and controls, or by functional studies.