Phenylpropanoid derivatives from Clausena harmandiana fruits

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• 作者：Wisanu Maneerat^a ; Wong Phakhodee^a ; Thunwadee Ritthiwigrom^b ; Sarot Cheenpracha^c ; Suwanna Deachathai^a ; Surat Laphookhieo^a ; ^{surat@mfu.ac.th} ; ^{s.laphookhieo@sci.mfu.ac.th}
• 关键词：Clausena harmandiana ; Phenylpropanoid ; Harmandianone ; Antibacterial ; Rutaceae
• 刊名：Phytochemistry Letters
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：6
• 期：1
• 页码：18-20
• 全文大小：202 K

文摘

A new phenylpropanoid derivative, harmandianone (1), along with four known compounds: verimol B (2), (E)-3-(2-hydroxy-4-methoxy-phenyl)propanoate (3), (E)-methyl p-coumarate (4), and (E)-5-methoxy-2-(prop-1-enyl)phenol (5) was isolated from the acetone extract of Clausena harmandiana fruits. All structures were characterized by spectroscopic methods (UV, IR, NMR and ESI-TOF-MS). Compounds 1 and 3-5 demonstrated weak antibacterial activity against Escherichia coli TISTR 780, methicillin-resistant Staphylococcus aureus SK1, Salmonella typhimurium TISTR 292 and S. aureus TISTR1466, with MIC values between 64 and 128 ¦Ìg/mL.