文摘
At therapeutic doses, lithium activates β-catenin only in physiologically vulnerable neurons, such as thalamic neurons. In thalamic neurons, nuclear accumulation of β-catenin is facilitated by TCF7L2. Tcf7l2 depletion attenuates nuclear accumulation of β-catenin and lithium-sensitive behavior. TCF7L2-dependent activation of β-catenin in thalamic neurons may contribute to therapeutic effects of lithium.